| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor UFO |
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| Ligand | BDBM50382444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_815463 (CHEMBL2027231) |
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| IC50 | 100±n/a nM |
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| Citation |  Mollard, A; Warner, SL; Call, LT; Wade, ML; Bearss, JJ; Verma, A; Sharma, S; Vankayalapati, H; Bearss, DJ Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors. ACS Med Chem Lett2:907-912 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor UFO |
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| Name: | Tyrosine-protein kinase receptor UFO |
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| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 98316.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30530 |
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| Residue: | 894 |
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| Sequence: | MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
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| BDBM50382444 |
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| n/a |
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| Name | BDBM50382444 |
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| Synonyms: | CHEMBL2023352 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N7O |
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| Mol. Mass. | 467.5655 |
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| SMILES | Cc1c[nH]c2nc(Nc3ccc(cc3)N3CCN(CCO)CC3)nc(-c3cccc(CC#N)c3)c12 |
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| Structure | 
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