| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2b |
|---|
| Ligand | BDBM50382493 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_816304 (CHEMBL2026980) |
|---|
| Ki | 158.49±n/a nM |
|---|
| Citation |  Congreve, M; Andrews, SP; Doré, AS; Hollenstein, K; Hurrell, E; Langmead, CJ; Mason, JS; Ng, IW; Tehan, B; Zhukov, A; Weir, M; Marshall, FH Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. J Med Chem55:1898-903 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2b |
|---|
| Name: | Adenosine receptor A2b |
|---|
| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 36341.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 332 |
|---|
| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
|
|
|
|---|
| BDBM50382493 |
|---|
| n/a |
|---|
| Name | BDBM50382493 |
|---|
| Synonyms: | CHEMBL2024116 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14FN5 |
|---|
| Mol. Mass. | 295.3143 |
|---|
| SMILES | Cc1cc(cc(C)n1)-c1nnc(N)nc1-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
