Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetFree fatty acid receptor 1
LigandBDBM50339476
Substrate/Competitorn/a
Meas. Tech.ChEMBL_816331 (CHEMBL2027153)
Ki 32±n/a nM
Citation Negoro, NSasaki, SIto, MKitamura, STsujihata, YIto, RSuzuki, MTakeuchi, KSuzuki, NMiyazaki, JSantou, TOdani, TKanzaki, NFunami, MTanaka, TYasuma, TMomose, Y Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists. J Med Chem55:1538-52 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Free fatty acid receptor 1
Name:Free fatty acid receptor 1
Synonyms:FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:31473.32
Organism:Homo sapiens (Human)
Description:O14842
Residue:300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339476
n/a
NameBDBM50339476
Synonyms:3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]-2-fluorophenyl}propanoic Acid | CHEMBL1688473
TypeSmall organic molecule
Emp. Form.C24H23FO3
Mol. Mass.378.436
SMILESCc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)c(F)c2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: