| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
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| Ligand | BDBM50382913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_815280 (CHEMBL2026495) |
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| IC50 | 0.3±n/a nM |
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| Citation |  Graham, TH; Liu, W; Verras, A; Sebhat, IK; Xiong, Y; Bleasby, K; Bhatt, UR; Chen, Q; Garcia-Calvo, M; Geissler, WM; Gorski, JN; He, H; Lassman, ME; Lisnock, J; Li, X; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xiao, J; Xie, D; Xu, S; Hale, JJ; Pinto, S; Shen, DM A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorg Med Chem Lett22:2811-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal Pro-X carboxypeptidase |
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| Name: | Lysosomal Pro-X carboxypeptidase |
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| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55028.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1335505 |
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| Residue: | 491 |
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| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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| BDBM50382913 |
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| n/a |
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| Name | BDBM50382913 |
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| Synonyms: | CHEMBL2023210 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32ClF3N4O |
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| Mol. Mass. | 545.039 |
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| SMILES | CC(C)(C)N1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC(CC1)c1ccnn1-c1ccc(F)c(Cl)c1 |r| |
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| Structure | 
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