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TargetLysosomal Pro-X carboxypeptidase
LigandBDBM50382914
Substrate/Competitorn/a
Meas. Tech.ChEMBL_815280 (CHEMBL2026495)
IC50 1.4±n/a nM
Citation Graham, THLiu, WVerras, ASebhat, IKXiong, YBleasby, KBhatt, URChen, QGarcia-Calvo, MGeissler, WMGorski, JNHe, HLassman, MELisnock, JLi, XShen, ZTong, XTung, ECWiltsie, JXiao, JXie, DXu, SHale, JJPinto, SShen, DM A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorg Med Chem Lett22:2811-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal Pro-X carboxypeptidase
Name:Lysosomal Pro-X carboxypeptidase
Synonyms:PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:PROTEIN
Mol. Mass.:55028.96
Organism:Mus musculus
Description:ChEMBL_1335505
Residue:491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382914
n/a
NameBDBM50382914
Synonyms:CHEMBL2023211
TypeSmall organic molecule
Emp. Form.C30H34ClF3N4O
Mol. Mass.559.065
SMILESCc1cc(C2CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)n(n1)-c1cc(Cl)ccc1F |r|
Structure
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