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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50382932 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_819962 (CHEMBL2032549) | ||
| IC50 | 2.8±n/a nM | ||
| Citation |  Xue, CB; Wang, A; Han, Q; Zhang, Y; Cao, G; Feng, H; Huang, T; Zheng, C; Xia, M; Zhang, K; Kong, L; Glenn, J; Anand, R; Meloni, D; Robinson, DJ; Shao, L; Storace, L; Li, M; Hughes, RO; Devraj, R; Morton, PA; Rogier, DJ; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Metcalf, B Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med Chem Lett2:913-918 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C CKR-2 | CC-CKR-2 | CCR-2 | CCR2_RAT | CD_antigen=CD192 | Ccr2 | Cmkbr2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 42771.06 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_819962 | ||
| Residue: | 373 | ||
| Sequence: |
| ||
| BDBM50382932 | |||
| n/a | |||
| Name | BDBM50382932 | ||
| Synonyms: | CHEMBL2029422 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H31F3N6O3 | ||
| Mol. Mass. | 568.59 | ||
| SMILES | O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccc(cn1)-c1ncccn1 |r,wU:4.7,wD:8.8,1.0,(25.05,5.32,;26.39,4.55,;27.72,3.79,;29.05,4.55,;29.05,6.09,;27.72,6.87,;26.39,6.09,;30.38,6.86,;31.72,6.08,;31.73,4.55,;33.2,4.09,;34.1,5.35,;33.17,6.58,;35.42,6.13,;35.41,7.67,;36.76,5.37,;38.09,6.15,;39.43,5.39,;39.44,3.85,;40.76,6.17,;40.74,7.71,;42.06,8.48,;43.41,7.73,;43.42,6.18,;42.09,5.4,;44.76,5.41,;44.77,3.87,;46.09,6.19,;46,4.52,;25.06,3.78,;23.72,4.55,;22.39,3.78,;22.39,2.24,;23.74,1.47,;25.06,2.24,;21.06,1.46,;19.73,2.22,;18.4,1.45,;18.4,-.09,;19.75,-.86,;21.07,-.08,)| | ||
| Structure | 
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