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TargetIGF-like family receptor 1
LigandBDBM50382959
Substrate/Competitorn/a
Meas. Tech.ChEMBL_817987 (CHEMBL2033413)
Kd>10000±n/a nM
Citation Rowbottom, MWFaraoni, RChao, QCampbell, BTLai, AGSetti, EEzawa, MSprankle, KGAbraham, STran, LStruss, BGibney, MArmstrong, RCGunawardane, RNNepomuceno, RRValenta, IHua, HGardner, MFCramer, MDGitnick, DInsko, DEApuy, JLJones-Bolin, SGhose, AKHerbertz, TAtor, MADorsey, BDRuggeri, BWilliams, MBhagwat, SJames, JHolladay, MW Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. J Med Chem55:1082-105 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
IGF-like family receptor 1
Name:IGF-like family receptor 1
Synonyms:IGFLR1 | IGFR1_HUMAN | TMEM149 | Transmembrane protein 149 | U2 small nuclear RNA auxiliary factor 1-like 4 | U2AF1L4
Type:PROTEIN
Mol. Mass.:37897.21
Organism:Homo sapiens (Human)
Description:ChEMBL_1510617
Residue:355
Sequence:
MGPGRCLLTALLLLALAPPPEASQYCGRLEYWNPDNKCCSSCLQRFGPPPCPDYEFRENC
GLNDHGDFVTPPFRKCSSGQCNPDGAELCSPCGGGAVTPTPAAGGGRTPWRCRERPVPAK
GHCPLTPGNPGAPSSQERSSPASSIAWRTPEPVPQQAWPNFLPLVVLVLLLTLAVIAILL
FILLWHLCWPKEKADPYPYPGLVCGVPNTHTPSSSHLSSPGALETGDTWKEASLLPLLSR
ELSSLASQPLSRLLDELEVLEELIVLLDPEPGPGGGMAHGTTRHLAARYGLPAAWSTFAY
SLRPSRSPLRALIEMVVAREPSASLGQLGTHLAQLGRADALRVLSKLGSSGVCWA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382959
n/a
NameBDBM50382959
Synonyms:CEP-32496 | CHEMBL2029988 | US9730937, Example 261
TypeSmall organic molecule
Emp. Form.C24H22F3N5O5
Mol. Mass.517.4572
SMILESCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
Structure
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