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TargetRelaxin-3 receptor 1
LigandBDBM50382996
Substrate/Competitorn/a
Meas. Tech.ChEMBL_818425 (CHEMBL2034745)
Ki>10000±n/a nM
Citation Shabanpoor, F; Akhter Hossain, M; Ryan, PJ; Belgi, A; Layfield, S; Kocan, M; Zhang, S; Samuel, CS; Gundlach, AL; Bathgate, RA; Separovic, F; Wade, JD Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J Med Chem55:1671-81 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Relaxin-3 receptor 1
Name:Relaxin-3 receptor 1
Synonyms:G protein-coupled receptor SALPR | G-protein coupled receptor GPCR135 | GPCR135 | RL3R1_HUMAN | RLN3 receptor 1 | RLN3R1 | RXFP3 | Relaxin family peptide receptor 3 | SALPR | Somatostatin- and angiotensin-like peptide receptor
Type:PROTEIN
Mol. Mass.:51139.41
Organism:Homo sapiens (Human)
Description:ChEMBL_818423
Residue:469
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGA
PPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLF
VTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTR
YHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK
VMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAA
GTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFS
QEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTA
TTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
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  Blast E-value cutoff:
BDBM50382996
n/a
NameBDBM50382996
Synonyms:CHEMBL2030694
TypeSmall organic molecule
Emp. Form.C133H207N43O34S2
Mol. Mass.3016.464
SMILESCC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r,wU:131.134,121.124,114.115,102.112,94.95,75.80,45.51,28.30,12.12,4.4,160.163,161.166,181.184,198.201,wD:126.129,83.91,69.72,54.62,34.42,17.24,8.8,2.2,149.151,167.170,187.190,(50.06,-42.67,;50.06,-44.21,;51.4,-44.97,;52.73,-44.21,;51.4,-46.52,;50.06,-47.29,;48.73,-46.52,;48.73,-44.98,;47.4,-47.3,;46.07,-46.53,;44.73,-47.3,;44.73,-48.84,;43.4,-46.53,;43.4,-44.99,;42.06,-47.3,;40.74,-46.53,;40.74,-44.99,;39.41,-47.3,;39.41,-48.84,;40.74,-49.61,;40.74,-51.15,;42.07,-51.92,;42.07,-53.46,;40.74,-54.23,;43.4,-54.23,;38.06,-46.54,;36.74,-47.31,;36.74,-48.84,;35.41,-46.54,;35.41,-45,;36.74,-44.23,;34.07,-47.31,;32.74,-46.55,;32.74,-45,;31.4,-47.32,;31.4,-48.85,;32.74,-49.63,;34.07,-48.85,;35.41,-49.62,;35.41,-51.15,;34.08,-51.92,;32.74,-51.16,;30.08,-46.55,;28.73,-47.32,;28.73,-48.86,;27.41,-46.55,;27.41,-45.01,;28.73,-44.24,;28.73,-42.7,;27.4,-41.93,;30.06,-41.93,;26.07,-47.32,;24.74,-46.55,;24.74,-45.01,;23.4,-47.33,;23.4,-48.86,;24.74,-49.63,;24.74,-51.17,;26.08,-51.94,;26.08,-53.47,;24.73,-54.25,;27.41,-54.25,;22.07,-46.56,;20.73,-47.33,;20.73,-48.87,;19.4,-46.56,;18.07,-47.34,;16.73,-46.56,;16.73,-45.02,;15.4,-47.33,;15.4,-48.88,;16.73,-49.64,;14.07,-46.57,;12.73,-47.34,;12.73,-48.87,;11.4,-46.57,;11.4,-45.03,;12.73,-44.26,;12.73,-42.72,;14.07,-45.03,;10.07,-47.34,;8.74,-46.58,;8.74,-45.03,;7.4,-47.35,;7.4,-48.88,;8.74,-49.66,;8.74,-51.19,;10.07,-51.96,;10.07,-53.5,;8.75,-54.26,;11.41,-54.27,;6.07,-46.58,;4.74,-47.35,;4.74,-48.89,;3.4,-46.58,;2.06,-47.35,;.74,-46.58,;.74,-45.04,;-.61,-47.36,;-1.93,-46.59,;-3.26,-47.36,;-3.26,-48.9,;-4.6,-46.59,;-4.6,-45.05,;-3.26,-44.28,;-1.93,-45.04,;-.6,-44.27,;-.6,-42.73,;.73,-41.96,;-1.94,-41.97,;-3.27,-42.74,;-5.93,-47.36,;-7.26,-46.59,;-8.59,-47.36,;-7.26,-45.05,;-5.88,-44.35,;-6.43,-42.75,;-8.1,-42.77,;-8.6,-44.37,;-10.03,-44.97,;-10.31,-46.49,;-11.21,-43.97,;-10.91,-42.46,;-12.65,-44.48,;-13.83,-43.48,;-13.55,-41.97,;-15.28,-44,;-15.56,-45.5,;-16.44,-42.99,;-17.9,-43.5,;-18.18,-45.02,;-19.07,-42.5,;-20.52,-43.02,;-18.78,-40.99,;-17.34,-40.47,;-17.05,-38.97,;-15.6,-38.45,;-15.32,-36.94,;-13.87,-36.43,;-16.49,-35.93,;3.4,-45.04,;4.74,-44.27,;2.06,-44.27,;47.4,-48.83,;48.73,-49.6,;46.07,-49.6,;52.73,-47.29,;52.73,-48.83,;54.07,-46.51,;55.4,-47.29,;55.4,-48.82,;56.73,-49.6,;58.07,-48.82,;59.39,-49.59,;59.4,-51.12,;58.07,-51.89,;56.74,-51.13,;56.73,-46.52,;56.73,-44.97,;58.06,-47.28,;59.4,-46.51,;59.4,-44.97,;58.06,-44.19,;60.73,-44.2,;60.73,-47.28,;60.73,-48.81,;62.07,-46.51,;63.39,-47.27,;63.39,-48.81,;64.73,-49.58,;64.73,-46.5,;64.73,-44.96,;66.06,-47.27,;67.4,-46.5,;68.73,-47.27,;68.73,-48.81,;70.06,-46.5,;71.39,-47.27,;72.73,-46.49,;72.73,-44.95,;74.06,-47.26,;75.4,-46.49,;75.4,-44.94,;76.73,-44.18,;76.73,-47.26,;76.73,-48.8,;78.06,-46.48,;79.39,-47.26,;79.39,-48.79,;80.73,-49.57,;80.73,-51.1,;82.06,-51.87,;82.06,-53.41,;80.74,-54.17,;83.4,-54.18,;80.73,-46.49,;80.73,-44.94,;82.06,-47.25,;83.39,-46.48,;83.39,-44.94,;84.73,-44.17,;86.13,-44.79,;87.16,-43.65,;86.39,-42.31,;86.86,-40.85,;85.83,-39.7,;84.33,-40.03,;83.85,-41.49,;84.89,-42.64,;84.73,-47.25,;86.07,-46.48,;84.73,-48.78,)|
Structure
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