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TargetRelaxin-3 receptor 1
LigandBDBM50382997
Substrate/Competitorn/a
Meas. Tech.ChEMBL_818425 (CHEMBL2034745)
Ki>10000±n/a nM
Citation Shabanpoor, F; Akhter Hossain, M; Ryan, PJ; Belgi, A; Layfield, S; Kocan, M; Zhang, S; Samuel, CS; Gundlach, AL; Bathgate, RA; Separovic, F; Wade, JD Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J Med Chem55:1671-81 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Relaxin-3 receptor 1
Name:Relaxin-3 receptor 1
Synonyms:G protein-coupled receptor SALPR | G-protein coupled receptor GPCR135 | GPCR135 | RL3R1_HUMAN | RLN3 receptor 1 | RLN3R1 | RXFP3 | Relaxin family peptide receptor 3 | SALPR | Somatostatin- and angiotensin-like peptide receptor
Type:PROTEIN
Mol. Mass.:51139.41
Organism:Homo sapiens (Human)
Description:ChEMBL_818423
Residue:469
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGA
PPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLF
VTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTR
YHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK
VMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAA
GTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFS
QEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTA
TTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382997
n/a
NameBDBM50382997
Synonyms:CHEMBL2030695
TypeSmall organic molecule
Emp. Form.C139H220N44O35
Mol. Mass.3067.5079
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r,wU:105.108,95.98,88.89,76.86,68.69,49.54,19.25,4.4,131.133,147.149,166.169,167.172,187.190,204.207,wD:100.103,57.65,43.46,28.36,8.16,2.2,120.122,140.142,148.151,155.157,173.176,193.196,(14.09,5.37,;14.09,3.83,;15.44,3.06,;16.76,3.83,;15.44,1.52,;14.09,.74,;12.76,1.51,;12.76,3.06,;11.43,.75,;11.43,-.8,;12.76,-1.57,;14.1,-.79,;15.42,-1.56,;15.43,-3.1,;14.09,-3.87,;12.77,-3.1,;10.08,1.51,;8.76,.74,;8.76,-.8,;7.43,1.51,;7.43,3.05,;8.76,3.82,;8.76,5.37,;7.42,6.13,;10.09,6.13,;6.09,.74,;4.76,1.5,;4.76,3.05,;3.42,.73,;3.42,-.81,;4.76,-1.58,;4.76,-3.11,;6.08,-3.89,;6.08,-5.42,;4.76,-6.19,;7.44,-6.19,;2.08,1.5,;.75,.73,;.75,-.81,;-.58,1.5,;-1.92,.73,;-3.25,1.5,;-3.25,3.04,;-4.58,.72,;-4.58,-.81,;-3.25,-1.59,;-5.91,1.49,;-7.26,.72,;-7.26,-.82,;-8.59,1.49,;-8.59,3.03,;-7.26,3.8,;-7.26,5.34,;-5.93,3.03,;-9.92,.71,;-11.26,1.48,;-11.26,3.03,;-12.6,.72,;-12.6,-.83,;-11.26,-1.6,;-11.26,-3.14,;-9.91,-3.91,;-9.91,-5.44,;-11.26,-6.21,;-8.58,-6.22,;-13.93,1.48,;-15.27,.71,;-15.27,-.83,;-16.6,1.48,;-17.94,.71,;-19.26,1.47,;-19.26,3.02,;-20.6,.7,;-21.94,1.47,;-23.27,.7,;-23.27,-.84,;-24.6,1.46,;-24.6,3.01,;-23.27,3.78,;-21.95,3.02,;-20.62,3.8,;-20.63,5.33,;-19.29,6.1,;-21.97,6.1,;-23.28,5.32,;-25.93,.69,;-27.27,1.46,;-28.61,.69,;-27.27,3.01,;-25.89,3.71,;-26.43,5.32,;-28.11,5.29,;-28.62,3.69,;-29.93,2.88,;-29.96,1.34,;-31.24,3.69,;-31.18,5.23,;-32.6,2.96,;-33.91,3.76,;-33.86,5.3,;-35.26,3.03,;-35.31,1.5,;-36.57,3.84,;-37.93,3.11,;-37.98,1.57,;-39.24,3.92,;-40.59,3.19,;-39.2,5.47,;-37.84,6.2,;-37.79,7.74,;-36.43,8.47,;-36.39,10.01,;-35.03,10.74,;-37.7,10.83,;-16.6,3.02,;-15.27,3.79,;-17.94,3.8,;16.76,.75,;16.76,-.79,;18.09,1.52,;19.42,.75,;19.42,-.78,;20.77,-1.56,;20.77,-3.09,;22.1,-3.86,;22.1,-5.41,;20.77,-6.17,;23.43,-6.17,;20.77,1.53,;20.77,3.07,;22.1,.76,;23.43,1.53,;23.43,3.07,;24.76,3.84,;24.76,5.38,;26.09,6.15,;26.09,7.71,;24.76,.76,;24.76,-.78,;26.1,1.53,;27.43,.76,;27.43,-.78,;28.76,-1.55,;26.1,-1.54,;28.76,1.53,;28.76,3.08,;30.1,.77,;31.43,1.54,;31.43,3.08,;32.76,3.85,;30.1,3.86,;30.1,5.39,;32.76,.77,;32.76,-.76,;34.1,1.54,;35.43,.78,;35.43,-.77,;36.77,-1.53,;38.1,-.76,;39.43,-1.53,;39.44,-3.07,;38.1,-3.84,;36.77,-3.07,;36.77,1.55,;36.77,3.09,;38.1,.77,;39.43,1.55,;39.43,3.09,;38.1,3.86,;40.77,3.86,;40.77,.78,;40.77,-.76,;42.11,1.55,;43.43,.78,;43.43,-.75,;44.77,-1.53,;44.77,1.56,;44.77,3.1,;46.1,.79,;47.44,1.56,;48.77,.79,;48.77,-.75,;50.11,1.56,;51.44,.79,;52.78,1.56,;52.78,3.11,;54.11,.8,;55.44,1.57,;55.44,3.11,;56.78,3.88,;56.78,.8,;56.78,-.73,;58.12,1.57,;59.44,.81,;59.44,-.74,;60.78,-1.5,;60.78,-3.05,;62.12,-3.82,;62.12,-5.35,;60.79,-6.12,;63.46,-6.13,;60.78,1.58,;60.78,3.12,;62.11,.8,;63.45,1.58,;63.45,3.12,;64.78,3.89,;66.18,3.27,;67.21,4.42,;66.44,5.74,;66.92,7.21,;65.89,8.37,;64.38,8.04,;63.91,6.57,;64.94,5.43,;64.78,.81,;66.12,1.58,;64.78,-.73,)|
Structure
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