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TargetLysosomal acid glucosylceramidase
LigandBDBM50383324
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820004 (CHEMBL2032679)
pH5±n/a
Ki 6±n/a nM
Commentsextracted
Citation Goddard-Borger, EDTropak, MBYonekawa, STysoe, CMahuran, DJWithers, SG Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease. J Med Chem55:2737-45 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal acid glucosylceramidase
Name:Lysosomal acid glucosylceramidase
Synonyms:Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (Human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM50383324
n/a
NameBDBM50383324
Synonyms:CHEMBL2029777
TypeSmall organic molecule
Emp. Form.C12H23NO3S
Mol. Mass.261.381
SMILESO[C@@H]1CN[C@H](CCSC2CCCC2)[C@H](O)[C@H]1O |r|
Structure
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