| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50383426 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_818260 (CHEMBL2034221) |
|---|
| IC50 | 0.9±n/a nM |
|---|
| Citation |  Graham, TH; Liu, W; Verras, A; Reibarkh, M; Bleasby, K; Bhatt, UR; Chen, Q; Garcia-Calvo, M; Geissler, WM; Gorski, JN; He, H; Lassman, ME; Lisnock, J; Li, X; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xie, D; Xu, S; Xiao, J; Hale, JJ; Pinto, S; Shen, DM A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes. Bioorg Med Chem Lett22:2818-22 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55028.96 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1335505 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
|
|
|
|---|
| BDBM50383426 |
|---|
| n/a |
|---|
| Name | BDBM50383426 |
|---|
| Synonyms: | CHEMBL2031589 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H30Cl2F2N4O |
|---|
| Mol. Mass. | 547.467 |
|---|
| SMILES | Cc1cc(C2CCN(CC2)C(=O)[C@@H]2C[C@@](C)(N)C[C@H]2c2ccc(F)cc2F)n(n1)-c1cc(Cl)ccc1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
