| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50383522 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_818576 (CHEMBL2032863) |
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| IC50 | 0.8±n/a nM |
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| Citation |  Mihalic, JT; Fan, P; Chen, X; Chen, X; Fu, Y; Motani, A; Liang, L; Lindstrom, M; Tang, L; Chen, JL; Jaen, J; Dai, K; Li, L Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition. Bioorg Med Chem Lett22:3781-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1 | MCHR1_MACMU |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42789.69 |
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| Organism: | Macaca mulatta |
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| Description: | ChEMBL_818576 |
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| Residue: | 388 |
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| Sequence: | ACAPGQGGRRWRLPQPAWVEGSSAWLWEPATGTGWMDLEASLLPTGPNTSNTSDGPDNLT
SAGSPPRSGSVSYINIIMPSVFGTICLLGIIGNSMVIFAVVKKSKLHWCNNVPDIFIINL
SVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLAT
VHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDL
YWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVF
FVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLS
VKPAAQGQLRAVSNAQTADEERTESKGT
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| BDBM50383522 |
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| n/a |
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| Name | BDBM50383522 |
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| Synonyms: | CHEMBL2032049 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33F3N2O2 |
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| Mol. Mass. | 462.5476 |
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| SMILES | C[C@@H]1[C@H]2CN(CCC3(CCCCC3)C(O)=O)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| |
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| Structure | 
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