| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 4 |
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| Ligand | BDBM50384266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820257 (CHEMBL2033344) |
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| IC50 | >300000±n/a nM |
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| Citation |  Chen, H; Tsalkova, T; Mei, FC; Hu, Y; Cheng, X; Zhou, J 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett22:4038-43 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 4 |
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| Name: | Rap guanine nucleotide exchange factor 4 |
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| Synonyms: | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115526.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504794 |
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| Residue: | 1011 |
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| Sequence: | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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| BDBM50384266 |
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| n/a |
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| Name | BDBM50384266 |
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| Synonyms: | CHEMBL2030605 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13N3OS |
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| Mol. Mass. | 235.305 |
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| SMILES | O=c1[nH]c(=S)[nH]c(C2CCCCC2)c1C#N |
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| Structure | 
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