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TargetSolute carrier family 12 member 5
LigandBDBM50384304
Substrate/Competitorn/a
Meas. Tech.ChEMBL_818163 (CHEMBL2033940)
IC50 1300±n/a nM
Citation Lebon, FPégurier, CLedecq, MMathieu, BBosman, NFrycia, ALengelé, SDhurke, KKanduluru, AKMeunier, SWagner, AWolff, CProvins, L Towards a KCC2 blocker pharmacophore model. Bioorg Med Chem Lett22:3978-82 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 12 member 5
Name:Solute carrier family 12 member 5
Synonyms:Kcc2 | S12A5_RAT | Slc12a5
Type:PROTEIN
Mol. Mass.:126249.28
Organism:Rattus norvegicus
Description:ChEMBL_818163
Residue:1139
Sequence:
MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKG
REYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384304
n/a
NameBDBM50384304
Synonyms:CHEMBL2030665
TypeSmall organic molecule
Emp. Form.C22H24N2O2
Mol. Mass.348.4382
SMILESCC(=O)N1CCCC1(Cc1ccccc1)C1=N[C@@H](CO1)c1ccccc1 |r,t:17|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: