Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apoptosis regulator Bcl-2 | ||
| Ligand | BDBM50384324 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_818165 (CHEMBL2033942) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Schroeder, GM; Wei, D; Banfi, P; Cai, ZW; Lippy, J; Menichincheri, M; Modugno, M; Naglich, J; Penhallow, B; Perez, HL; Sack, J; Schmidt, RJ; Tebben, A; Yan, C; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3951-6 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apoptosis regulator Bcl-2 | |||
| Name: | Apoptosis regulator Bcl-2 | ||
| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein | ||
| Type: | Homodimer or heterodimer | ||
| Mol. Mass.: | 26269.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P10415 | ||
| Residue: | 239 | ||
| Sequence: |
| ||
| BDBM50384324 | |||
| n/a | |||
| Name | BDBM50384324 | ||
| Synonyms: | CHEMBL2030859 | US9346795, 260 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C42H40N4O6S | ||
| Mol. Mass. | 728.855 | ||
| SMILES | CCCCc1c(c(CO)nn1-c1ccccc1)-c1ccc(cc1C(=O)N1Cc2ccccc2C[C@H]1CO)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |r,wU:34.39,(-8.12,-38.1,;-6.89,-39.03,;-5.47,-38.44,;-5.28,-36.91,;-3.85,-36.31,;-2.39,-35.82,;-2.4,-34.28,;-1.16,-33.36,;-1.34,-31.83,;-3.87,-33.82,;-4.77,-35.07,;-6.3,-34.97,;-6.98,-33.59,;-8.52,-33.49,;-9.37,-34.77,;-8.68,-36.16,;-7.15,-36.25,;-1.14,-36.72,;.21,-35.98,;1.54,-36.79,;1.49,-38.33,;.14,-39.06,;-1.18,-38.25,;-2.53,-38.98,;-3.84,-38.18,;-2.57,-40.52,;-1.26,-41.33,;-1.31,-42.87,;0,-43.68,;-.05,-45.22,;-1.41,-45.94,;-2.72,-45.13,;-2.67,-43.6,;-3.97,-42.79,;-3.93,-41.25,;-5.24,-40.45,;-6.59,-41.18,;2.8,-39.14,;4.16,-38.41,;2.76,-40.68,;4.07,-41.48,;4.86,-40.16,;5.61,-41.5,;4.03,-43.02,;2.67,-43.75,;2.62,-45.29,;3.95,-46.11,;3.93,-47.65,;5.25,-48.45,;6.61,-47.69,;6.63,-46.14,;5.3,-45.36,;5.34,-43.82,)| | ||
| Structure | 
| ||