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TargetApoptosis regulator Bcl-2
LigandBDBM50384356
Substrate/Competitorn/a
Meas. Tech.ChEMBL_818176 (CHEMBL2033953)
IC50 22±n/a nM
Citation Perez, HLBanfi, PBertrand, JCai, ZWGrebinski, JWKim, KLippy, JModugno, MNaglich, JSchmidt, RJTebben, AVianello, PWei, DDZhang, LGalvani, ALombardo, LJBorzilleri, RM Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3946-50 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM50384356
n/a
NameBDBM50384356
Synonyms:CHEMBL2031025 | US9346795, 105
TypeSmall organic molecule
Emp. Form.C45H52ClN5O7S
Mol. Mass.842.442
SMILESCCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1Cc2ccccc2C[C@H]1COCCCOC)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |r|
Structure
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