| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50384449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_821764 (CHEMBL2039061) |
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| IC50 | 800±n/a nM |
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| Citation |  Bergman, JA; Hahne, K; Song, J; Hrycyna, CA; Gibbs, RA S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase. ACS Med Chem Lett3:15-19 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50384449 |
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| n/a |
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| Name | BDBM50384449 |
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| Synonyms: | CHEMBL2035530 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31N3O2S |
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| Mol. Mass. | 449.608 |
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| SMILES | COC(=O)CCSC\C=C(/C)CCn1cc(CCc2ccc(cc2)-c2ccccc2)nn1 |
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| Structure | 
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