Reaction Details | |||
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Target | Tyrosine-protein kinase receptor UFO | ||
Ligand | BDBM50384577 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_820660 (CHEMBL2037931) | ||
IC50 | 57±n/a nM | ||
Citation | Liu, J; Yang, C; Simpson, C; Deryckere, D; Van Deusen, A; Miley, MJ; Kireev, D; Norris-Drouin, J; Sather, S; Hunter, D; Korboukh, VK; Patel, HS; Janzen, WP; Machius, M; Johnson, GL; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase receptor UFO | |||
Name: | Tyrosine-protein kinase receptor UFO | ||
Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 98316.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30530 | ||
Residue: | 894 | ||
Sequence: |
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BDBM50384577 | |||
n/a | |||
Name | BDBM50384577 | ||
Synonyms: | CHEMBL2036791 | US9744172, Compound UNC00000489A | ||
Type | Small organic molecule | ||
Emp. Form. | C22H31N9 | ||
Mol. Mass. | 421.5418 | ||
SMILES | CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1 |(38.98,-28.18,;40.32,-28.95,;41.65,-28.18,;41.65,-26.64,;42.98,-25.87,;44.32,-26.63,;45.79,-26.15,;46.7,-27.41,;45.79,-28.66,;46.27,-30.13,;45.24,-31.27,;43.73,-30.94,;42.7,-32.08,;43.17,-33.54,;42.14,-34.69,;44.68,-33.87,;45.72,-32.73,;44.32,-28.18,;42.98,-28.95,;46.27,-24.69,;45.24,-23.55,;45.71,-22.09,;47.22,-21.76,;48.25,-22.91,;47.77,-24.37,;47.69,-20.3,;49.2,-19.98,;49.67,-18.53,;48.64,-17.38,;47.14,-17.7,;46.65,-19.17,)| | ||
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