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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase receptor UFO | ||
| Ligand | BDBM50384608 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_820660 (CHEMBL2037931) | ||
| IC50 | 38±n/a nM | ||
| Citation |  Liu, J; Yang, C; Simpson, C; Deryckere, D; Van Deusen, A; Miley, MJ; Kireev, D; Norris-Drouin, J; Sather, S; Hunter, D; Korboukh, VK; Patel, HS; Janzen, WP; Machius, M; Johnson, GL; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase receptor UFO | |||
| Name: | Tyrosine-protein kinase receptor UFO | ||
| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 98316.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30530 | ||
| Residue: | 894 | ||
| Sequence: |
| ||
| BDBM50384608 | |||
| n/a | |||
| Name | BDBM50384608 | ||
| Synonyms: | CHEMBL2036801 | US9744172, Compound UNC00000471A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N6 | ||
| Mol. Mass. | 412.53 | ||
| SMILES | NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccccc4)nc23)CC1 |(19.2,-7.89,;20.24,-6.75,;19.77,-5.28,;20.8,-4.15,;22.3,-4.48,;23.33,-3.33,;22.86,-1.87,;23.77,-.61,;22.86,.64,;23.33,2.11,;24.84,2.42,;25.32,3.89,;24.29,5.03,;22.77,4.7,;22.3,3.24,;21.38,.16,;20.05,.93,;18.72,.16,;18.72,-1.39,;17.38,-2.16,;16.05,-1.39,;16.05,.15,;17.39,.91,;17.39,2.45,;16.06,3.22,;14.72,2.45,;14.72,.91,;20.05,-2.16,;21.38,-1.39,;22.78,-5.93,;21.74,-7.08,)| | ||
| Structure | 
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