| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50384714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820900 (CHEMBL2038841) |
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| Ki | 5±n/a nM |
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| Citation |  Haddach, M; Michaux, J; Schwaebe, MK; Pierre, F; Borsan, C; Tran, J; Raffaele, N; Ravula, S; Drygin, D; Siddiqui-Jain, A; Darjania, L; Stansfield, R; Proffitt, C; Macalino, D; Streiner, N; Bliesath, J; Omori, M; Whitten, JP; Anderes, K; Rice, WG; Ryckman, DM Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett3:135-139 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50384714 |
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| n/a |
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| Name | BDBM50384714 |
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| Synonyms: | CHEMBL2037200 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24ClN3O3 |
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| Mol. Mass. | 461.94 |
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| SMILES | CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 |
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| Structure | 
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