Reaction Details |
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Target | Tyrosine-protein kinase Fgr |
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Ligand | BDBM50384725 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_820930 (CHEMBL2038871) |
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IC50 | 5900±n/a nM |
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Citation | Albaugh, P; Fan, Y; Mi, Y; Sun, F; Adrian, F; Li, N; Jia, Y; Sarkisova, Y; Kreusch, A; Hood, T; Lu, M; Liu, G; Huang, S; Liu, Z; Loren, J; Tuntland, T; Karanewsky, DS; Seidel, HM; Molteni, V Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett3:140-145 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fgr |
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Name: | Tyrosine-protein kinase Fgr |
Synonyms: | FGR_MOUSE | Fgr | Proto-oncogene c-Fgr | p55-Fgr |
Type: | PROTEIN |
Mol. Mass.: | 58854.89 |
Organism: | Mus musculus |
Description: | ChEMBL_820930 |
Residue: | 517 |
Sequence: | MGCVFCKKLEPASKEDVGLEGDFRSQTAEERYFPDPTQGRTSSVFPQPTSPAFLNTGNMR
SISGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGHRGYVPSNY
VAPVDSIQAEEWYFGKISRKDAERQLLSSGNPQGAFLIRESETTKGAYSLSIRDWDQNRG
DHIKHYKIRKLDTGGYYITTRAQFDSIQDLVRHYMEVNDGLCYLLTAPCTTTKPQTLGLA
KDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKL
LRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAY
MERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALF
GRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVME
QAWRLDPEERPTFEYLQSFLEDYFTSTEPQYQPGDQT
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BDBM50384725 |
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n/a |
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Name | BDBM50384725 |
Synonyms: | CHEMBL2037209 |
Type | Small organic molecule |
Emp. Form. | C31H23F3N6O2 |
Mol. Mass. | 568.5485 |
SMILES | Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1 |
Structure |
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