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TargetTyrosine-protein kinase Fgr
LigandBDBM50384725
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820930 (CHEMBL2038871)
IC50 5900±n/a nM
Citation Albaugh, PFan, YMi, YSun, FAdrian, FLi, NJia, YSarkisova, YKreusch, AHood, TLu, MLiu, GHuang, SLiu, ZLoren, JTuntland, TKaranewsky, DSSeidel, HMMolteni, V Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett3:140-145 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Fgr
Name:Tyrosine-protein kinase Fgr
Synonyms:FGR_MOUSE | Fgr | Proto-oncogene c-Fgr | p55-Fgr
Type:PROTEIN
Mol. Mass.:58854.89
Organism:Mus musculus
Description:ChEMBL_820930
Residue:517
Sequence:
MGCVFCKKLEPASKEDVGLEGDFRSQTAEERYFPDPTQGRTSSVFPQPTSPAFLNTGNMR
SISGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGHRGYVPSNY
VAPVDSIQAEEWYFGKISRKDAERQLLSSGNPQGAFLIRESETTKGAYSLSIRDWDQNRG
DHIKHYKIRKLDTGGYYITTRAQFDSIQDLVRHYMEVNDGLCYLLTAPCTTTKPQTLGLA
KDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKL
LRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAY
MERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALF
GRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVME
QAWRLDPEERPTFEYLQSFLEDYFTSTEPQYQPGDQT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384725
n/a
NameBDBM50384725
Synonyms:CHEMBL2037209
TypeSmall organic molecule
Emp. Form.C31H23F3N6O2
Mol. Mass.568.5485
SMILESCc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Structure
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