Reaction Details |
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Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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Ligand | BDBM50384888 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_821806 (CHEMBL2039250) |
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IC50 | >3000±n/a nM |
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Citation | Cha, MY; Lee, KO; Kang, SJ; Jung, YH; Song, JY; Choi, KJ; Byun, JY; Lee, HJ; Lee, GS; Park, SB; Kim, MS Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases. J Med Chem55:2846-57 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
Synonyms: | AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1 |
Type: | Protein |
Mol. Mass.: | 64023.62 |
Organism: | Homo sapiens (Human) |
Description: | Q13131 |
Residue: | 559 |
Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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BDBM50384888 |
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n/a |
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Name | BDBM50384888 |
Synonyms: | CHEMBL2035810 |
Type | Small organic molecule |
Emp. Form. | C23H20ClN7O3 |
Mol. Mass. | 477.903 |
SMILES | Nc1ncnc(Nc2ccc(OCc3ccccn3)c(Cl)c2)c1-c1nc(CNC(=O)C=C)co1 |
Structure |
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