| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50384890 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820326 (CHEMBL2037748) |
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| IC50 | 177.83±n/a nM |
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| Citation |  Wang, Y; Guan, XL; Wu, PF; Wang, CM; Cao, H; Li, L; Guo, XJ; Wang, F; Xie, N; Jiang, FC; Chen, JG Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases. J Med Chem55:3588-92 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65643.35 |
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| Organism: | Equus caballus (Horse) |
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| Description: | P81908 |
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| Residue: | 574 |
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| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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| BDBM50384890 |
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| n/a |
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| Name | BDBM50384890 |
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| Synonyms: | CHEMBL2036263 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30ClN3OS |
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| Mol. Mass. | 420.011 |
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| SMILES | SCCC(=O)NCCCCCCNc1c2CCCCc2nc2cc(Cl)ccc12 |
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| Structure | 
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