Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent serotonin transporter |
---|
Ligand | BDBM50151982 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_821406 (CHEMBL2037807) |
---|
Ki | 0.5±n/a nM |
---|
Citation | Zhu, XY; Etukala, JR; Eyunni, SV; Setola, V; Roth, BL; Ablordeppey, SY Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. Eur J Med Chem53:124-32 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent serotonin transporter |
---|
Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
BDBM50151982 |
---|
n/a |
---|
Name | BDBM50151982 |
Synonyms: | 5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide | CHEMBL439849 | VILAZODONE |
Type | Small organic molecule |
Emp. Form. | C26H27N5O2 |
Mol. Mass. | 441.5249 |
SMILES | NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1 |
Structure |
|