| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM50385105 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_821529 (CHEMBL2038197) |
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| Ki | 0.43±n/a nM |
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| Citation |  Shiohara, H; Nakamura, T; Kikuchi, N; Ozawa, T; Nagano, R; Matsuzawa, A; Ohnota, H; Miyamoto, T; Ichikawa, K; Hashizume, K Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia. Bioorg Med Chem20:3622-34 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50385105 |
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| n/a |
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| Name | BDBM50385105 |
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| Synonyms: | CHEMBL2035874 | US10322118, Entry 8b |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17Br2NO5 |
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| Mol. Mass. | 487.139 |
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| SMILES | CC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(O)=O)cc2Br)ccc1O |
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| Structure | 
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