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TargetHematopoietic prostaglandin D synthase
LigandBDBM50385145
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823084 (CHEMBL2039155)
IC50 662±n/a nM
Citation Trujillo, JIKiefer, JRHuang, WDay, JEMoon, JJerome, GMBono, CPKornmeier, CMWilliams, MLKuhn, CRennie, GRWynn, TACarron, CPThorarensen, A Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg Med Chem Lett22:3795-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hematopoietic prostaglandin D synthase
Name:Hematopoietic prostaglandin D synthase
Synonyms:GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM50385145
n/a
NameBDBM50385145
Synonyms:CHEMBL2035654
TypeSmall organic molecule
Emp. Form.C23H24N2O3
Mol. Mass.376.4483
SMILESOc1ccc2ccccc2c1-c1ccc(cc1)C(=O)NCCN1CCOCC1
Structure
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