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TargetProstaglandin D Synthase
LigandBDBM50385147
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823084
IC50 845±n/a nM
Citation Trujillo JIKiefer JRHuang WDay JEMoon JJerome GMBono CPKornmeier CMWilliams MLKuhn CRennie GRWynn TACarron CPThorarensen A Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg Med Chem Lett 22:3795-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM50385147
n/a
NameBDBM50385147
Synonyms:CHEMBL2035656
TypeSmall organic molecule
Emp. Form.C24H27N3O2
Mol. Mass.389.4901
SMILESNCc1ccc2ccccc2c1-c1ccc(cc1)C(=O)NCCN1CCOCC1
Structure
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