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TargetThioredoxin reductase 1, cytoplasmic
LigandBDBM50385288
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822563 (CHEMBL2039583)
IC50 280±n/a nM
Citation He, JLi, DXiong, KGe, YJin, HZhang, GHong, MTian, YYin, JZeng, H Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy. Bioorg Med Chem20:3816-27 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 1, cytoplasmic
Name:Thioredoxin reductase 1, cytoplasmic
Synonyms:NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1
Type:PROTEIN
Mol. Mass.:54519.34
Organism:Rattus norvegicus
Description:ChEMBL_589950
Residue:498
Sequence:
MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
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BDBM50385288
n/a
NameBDBM50385288
Synonyms:CHEMBL2034987
TypeSmall organic molecule
Emp. Form.C16H10F2N2O2Se2
Mol. Mass.458.18
SMILESFc1ccc2[se]n(CCn3[se]c4ccc(F)cc4c3=O)c(=O)c2c1
Structure
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