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TargetCalcitonin gene-related peptide type 1 receptor
LigandBDBM50385309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822703
Ki 19±n/a nM
Citation Bell IMStump CAGallicchio SNStaas DDZartman CBMoore ELSain NUrban MBruno JGCalamari AKemmerer ALMosser SDFandozzi CWhite RBZrada MMSelnick HGGraham SLVacca JPKane SASalvatore CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett 22:3941-5 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide type 1 receptor
Name:Calcitonin gene-related peptide type 1 receptor
Synonyms:CGRP type 1 receptor | Calcitonin receptor-like receptor | Calcrl | Crlr
Type:PROTEIN
Mol. Mass.:53266.80
Organism:Mus musculus
Description:ChEMBL_822703
Residue:463
Sequence:
MDKKHILCFLVLLPLNMALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQAE
GLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTW
TNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLF
FSFICNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLI
VVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAA
LLVNLFFLLNIVRVLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVA
EEVYDYVMHILMHFQGLLVATIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASY
TVSTISDMQGYSHDCPTEHLNGKSIQDIENVALKSENMYDLVM
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  Blast E-value cutoff:
BDBM50385309
n/a
NameBDBM50385309
Synonyms:CHEMBL2035983
TypeSmall organic molecule
Emp. Form.C31H30F2N6O3
Mol. Mass.572.6051
SMILESC[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure
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