| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
|---|
| Ligand | BDBM50385314 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_822689 |
|---|
| Ki | 3.4±n/a nM |
|---|
| Citation |  Bell IM; Stump CA; Gallicchio SN; Staas DD; Zartman CB; Moore EL; Sain N; Urban M; Bruno JG; Calamari A; Kemmerer AL; Mosser SD; Fandozzi C; White RB; Zrada MM; Selnick HG; Graham SL; Vacca JP; Kane SA; Salvatore CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett 22:3941-5 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcitonin gene-related peptide type 1 receptor |
|---|
| Name: | Calcitonin-gene-related peptide receptor; CALCRL/RAMP1 |
|---|
| Synonyms: | n/a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53330.91 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1457286 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQG
EGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRT
WTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNL
FFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKV
AEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSAS
YTVSTISDVQGYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM
|
|
|
|---|
| BDBM50385314 |
|---|
| n/a |
|---|
| Name | BDBM50385314 |
|---|
| Synonyms: | CHEMBL2035981 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H31F2N5O3 |
|---|
| Mol. Mass. | 571.617 |
|---|
| SMILES | C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
