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TargetIsoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
LigandBDBM50385309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822725 (CHEMBL2040042)
Ki 0.640000±n/a nM
Citation Bell, IMStump, CAGallicchio, SNStaas, DDZartman, CBMoore, ELSain, NUrban, MBruno, JGCalamari, AKemmerer, ALMosser, SDFandozzi, CWhite, RBZrada, MMSelnick, HGGraham, SLVacca, JPKane, SASalvatore, CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett22:3941-5 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
Name:Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
Synonyms:Amylin receptor AMY1, CALCR/RAMP1 | Calcitonin receptor (1)/Receptor activity-modifying protein 1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 822725
Components:This complex has 2 components.
Component 1
Name:Isoform 1 of Calcitonin receptor (1)
Synonyms:CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1)
Type:PROTEIN
Mol. Mass.:55343.05
Organism:Homo sapiens (Human)
Description:ChEMBL_42610
Residue:474
Sequence:
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
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Component 2
Name:Receptor activity-modifying protein 1
Synonyms:Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:PROTEIN
Mol. Mass.:16992.80
Organism:Homo sapiens (Human)
Description:EBI_100673
Residue:148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
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Component 3
Name:Isoform 1 of Calcitonin receptor (1)
Synonyms:CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1)
Type:PROTEIN
Mol. Mass.:55343.05
Organism:Homo sapiens (Human)
Description:ChEMBL_42610
Residue:474
Sequence:
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
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BDBM50385309
n/a
NameBDBM50385309
Synonyms:CHEMBL2035983
TypeSmall organic molecule
Emp. Form.C31H30F2N6O3
Mol. Mass.572.6051
SMILESC[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure
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