Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetVoltage-gated potassium channel beta subunit Mink
LigandBDBM50385309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822731
IC50>20000±n/a nM
Citation Bell IMStump CAGallicchio SNStaas DDZartman CBMoore ELSain NUrban MBruno JGCalamari AKemmerer ALMosser SDFandozzi CWhite RBZrada MMSelnick HGGraham SLVacca JPKane SASalvatore CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett 22:3941-5 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel beta subunit Mink
Name:Voltage-gated potassium channel beta subunit Mink
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50385309
n/a
NameBDBM50385309
Synonyms:CHEMBL2035983
TypeSmall organic molecule
Emp. Form.C31H30F2N6O3
Mol. Mass.572.6051
SMILESC[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: