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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM50385353
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822749 (CHEMBL2040233)
IC50 450±n/a nM
Citation Banoglu, EÇaliskan, BLuderer, SEren, GÖzkan, YAltenhofen, WWeinigel, CBarz, DGerstmeier, JPergola, CWerz, O Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem20:3728-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM50385353
n/a
NameBDBM50385353
Synonyms:CHEMBL2036178
TypeSmall organic molecule
Emp. Form.C27H27N3
Mol. Mass.393.5234
SMILESCC(C)Cc1ccc(cc1)C(C)c1nc2ccccc2n1Cc1ccccc1C#N
Structure
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