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Target5-lipoxygenase/FLAP
LigandBDBM50385376
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822749
IC50 120±n/a nM
Citation Banoglu EÇaliskan BLuderer SEren GÖzkan YAltenhofen WWeinigel CBarz DGerstmeier JPergola CWerz O Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem 20:3728-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-lipoxygenase/FLAP
Name:5-lipoxygenase/FLAP
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM50385376
n/a
NameBDBM50385376
Synonyms:CHEMBL2036377
TypeSmall organic molecule
Emp. Form.C27H29ClN2O
Mol. Mass.432.985
SMILESCOc1ccc2n(Cc3ccccc3Cl)c(nc2c1)C(C)c1ccc(CC(C)C)cc1
Structure
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