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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50385403
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822962 (CHEMBL2038283)
IC50 23±n/a nM
Citation McCoull, WAddie, MSBirch, AMBirtles, SBuckett, LKButlin, RJBowker, SSBoyd, SChapman, SDavies, RDDonald, CSGreen, CPJenner, CKemmitt, PDLeach, AGMoody, GCGutierrez, PMNewcombe, NJNowak, TPacker, MJPlowright, ATRevill, JSchofield, PSheldon, CStokes, STurnbull, AVWang, SJWhalley, DPWood, JM Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett22:3873-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50385403
n/a
NameBDBM50385403
Synonyms:CHEMBL2036574
TypeSmall organic molecule
Emp. Form.C18H17FN6O2S
Mol. Mass.400.43
SMILESFc1ccccc1Nc1nnc(o1)C(=O)Nc1ccc(nc1)N1CCSCC1
Structure
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