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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50385426
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822962 (CHEMBL2038283)
IC50 540±n/a nM
Citation McCoull, WAddie, MSBirch, AMBirtles, SBuckett, LKButlin, RJBowker, SSBoyd, SChapman, SDavies, RDDonald, CSGreen, CPJenner, CKemmitt, PDLeach, AGMoody, GCGutierrez, PMNewcombe, NJNowak, TPacker, MJPlowright, ATRevill, JSchofield, PSheldon, CStokes, STurnbull, AVWang, SJWhalley, DPWood, JM Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett22:3873-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50385426
n/a
NameBDBM50385426
Synonyms:CHEMBL2036731
TypeSmall organic molecule
Emp. Form.C24H23N7O4
Mol. Mass.473.4839
SMILESO=C(Nc1ccc(nc1)N1CCOCC1)c1nnc(Nc2cccc(OCc3ccccn3)c2)o1
Structure
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