| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 1 |
|---|
| Ligand | BDBM50385671 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_826074 (CHEMBL2045505) |
|---|
| Ki | 7.4±n/a nM |
|---|
| Citation |  Kim, YS; Kil, MJ; Kang, SU; Ryu, H; Kim, MS; Cho, Y; Bhondwe, RS; Thorat, SA; Sun, W; Liu, K; Lee, JH; Choi, S; Pearce, LV; Pavlyukovets, VA; Morgan, MA; Tran, R; Lazar, J; Blumberg, PM; Lee, J N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorg Med Chem20:215-24 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 1 |
|---|
| Synonyms: | Capsaicin receptor | OTRPC1 | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Trpv1 | Vanilloid Receptor 1 (TRPV1, VR1) | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 (VRI/TRPV1) | Vanilloid receptor type 1-like | Vanilloid receptor type 1-like (TrpV1/Vr1) | Vr1 | Vr1l | osm-9-like TRP channel 1 |
|---|
| Type: | Transient Receptor |
|---|
| Mol. Mass.: | 94956.12 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | O35433 |
|---|
| Residue: | 838 |
|---|
| Sequence: | MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASP
LDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDA
VAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVA
RKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTK
GRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVD
NTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEP
ECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNR
LLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEIL
SVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVAS
MVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIE
DGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFI
ILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAF
RSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSG
RVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK
|
|
|
|---|
| BDBM50385671 |
|---|
| n/a |
|---|
| Name | BDBM50385671 |
|---|
| Synonyms: | CHEMBL2042384 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26F2N2O3S |
|---|
| Mol. Mass. | 424.505 |
|---|
| SMILES | CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1cc(F)c(NS(C)(=O)=O)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
