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TargetProlyl hydroxylase EGLN3
LigandBDBM50385791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823545 (CHEMBL2045988)
IC50 14±n/a nM
Citation Vachal, PMiao, SPierce, JMGuiadeen, DColandrea, VJWyvratt, MJSalowe, SPSonatore, LMMilligan, JAHajdu, RGollapudi, AKeohane, CALingham, RBMandala, SMDeMartino, JATong, XWolff, MSteinhuebel, DKieczykowski, GRFleitz, FJChapman, KAthanasopoulos, JAdam, GAkyuz, CDJena, DKLusen, JWMeng, JStein, BDXia, LSherer, ECHale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prolyl hydroxylase EGLN3
Name:Prolyl hydroxylase EGLN3
Synonyms:EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:Protein
Mol. Mass.:27265.54
Organism:Homo sapiens (Human)
Description:Q9H6Z9
Residue:239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
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  Blast E-value cutoff:
BDBM50385791
n/a
NameBDBM50385791
Synonyms:CHEMBL2041178
TypeSmall organic molecule
Emp. Form.C33H33N7O4
Mol. Mass.591.6596
SMILESCNC(=O)c1ccc(cc1)-c1ccc(cc1)N1C(=O)N(c2cc(OC)ncn2)C2(CCN(Cc3ncccc3C)CC2)C1=O
Structure
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