| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN3 |
|---|
| Ligand | BDBM50385799 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_823545 (CHEMBL2045988) |
|---|
| IC50 | 4.9±n/a nM |
|---|
| Citation |  Vachal, P; Miao, S; Pierce, JM; Guiadeen, D; Colandrea, VJ; Wyvratt, MJ; Salowe, SP; Sonatore, LM; Milligan, JA; Hajdu, R; Gollapudi, A; Keohane, CA; Lingham, RB; Mandala, SM; DeMartino, JA; Tong, X; Wolff, M; Steinhuebel, D; Kieczykowski, GR; Fleitz, FJ; Chapman, K; Athanasopoulos, J; Adam, G; Akyuz, CD; Jena, DK; Lusen, JW; Meng, J; Stein, BD; Xia, L; Sherer, EC; Hale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl hydroxylase EGLN3 |
|---|
| Name: | Prolyl hydroxylase EGLN3 |
|---|
| Synonyms: | EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 27265.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H6Z9 |
|---|
| Residue: | 239 |
|---|
| Sequence: | MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
|
|
|
|---|
| BDBM50385799 |
|---|
| n/a |
|---|
| Name | BDBM50385799 |
|---|
| Synonyms: | CHEMBL2041186 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H32N6O4 |
|---|
| Mol. Mass. | 576.645 |
|---|
| SMILES | Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1nccnc1C |
|---|
| Structure | 
|
|---|
Search and Browse
