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TargetEgl nine homolog 1
LigandBDBM50385813
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823543 (CHEMBL2045986)
IC50 0.4±n/a nM
Citation Vachal, PMiao, SPierce, JMGuiadeen, DColandrea, VJWyvratt, MJSalowe, SPSonatore, LMMilligan, JAHajdu, RGollapudi, AKeohane, CALingham, RBMandala, SMDeMartino, JATong, XWolff, MSteinhuebel, DKieczykowski, GRFleitz, FJChapman, KAthanasopoulos, JAdam, GAkyuz, CDJena, DKLusen, JWMeng, JStein, BDXia, LSherer, ECHale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Egl nine homolog 1
Name:Egl nine homolog 1
Synonyms:C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:Protein
Mol. Mass.:46035.59
Organism:Homo sapiens (Human)
Description:Q9GZT9
Residue:426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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BDBM50385813
n/a
NameBDBM50385813
Synonyms:CHEMBL2043168
TypeSmall organic molecule
Emp. Form.C32H30N6O5
Mol. Mass.578.6178
SMILESCOc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1)C(O)=O
Structure
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