| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50385800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_823569 (CHEMBL2046012) |
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| IC50 | >10000±n/a nM |
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| Citation |  Vachal, P; Miao, S; Pierce, JM; Guiadeen, D; Colandrea, VJ; Wyvratt, MJ; Salowe, SP; Sonatore, LM; Milligan, JA; Hajdu, R; Gollapudi, A; Keohane, CA; Lingham, RB; Mandala, SM; DeMartino, JA; Tong, X; Wolff, M; Steinhuebel, D; Kieczykowski, GR; Fleitz, FJ; Chapman, K; Athanasopoulos, J; Adam, G; Akyuz, CD; Jena, DK; Lusen, JW; Meng, J; Stein, BD; Xia, L; Sherer, EC; Hale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50385800 |
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| n/a |
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| Name | BDBM50385800 |
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| Synonyms: | CHEMBL2041187 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28N6O4 |
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| Mol. Mass. | 548.5918 |
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| SMILES | Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O)c1ncccn1 |
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| Structure | 
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