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TargetProlyl hydroxylase EGLN2
LigandBDBM50385809
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823544 (CHEMBL2045987)
IC50 1.4±n/a nM
Citation Vachal, PMiao, SPierce, JMGuiadeen, DColandrea, VJWyvratt, MJSalowe, SPSonatore, LMMilligan, JAHajdu, RGollapudi, AKeohane, CALingham, RBMandala, SMDeMartino, JATong, XWolff, MSteinhuebel, DKieczykowski, GRFleitz, FJChapman, KAthanasopoulos, JAdam, GAkyuz, CDJena, DKLusen, JWMeng, JStein, BDXia, LSherer, ECHale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prolyl hydroxylase EGLN2
Name:Prolyl hydroxylase EGLN2
Synonyms:EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:Protein
Mol. Mass.:43657.01
Organism:Homo sapiens (Human)
Description:Q96KS0
Residue:407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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  Blast E-value cutoff:
BDBM50385809
n/a
NameBDBM50385809
Synonyms:CHEMBL2043007
TypeSmall organic molecule
Emp. Form.C30H28N6O3
Mol. Mass.520.5817
SMILESCc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccccc1)c1ccnc(=O)[nH]1
Structure
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