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TargetProlyl hydroxylase EGLN2
LigandBDBM50385813
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823544 (CHEMBL2045987)
IC50 0.3±n/a nM
Citation Vachal, PMiao, SPierce, JMGuiadeen, DColandrea, VJWyvratt, MJSalowe, SPSonatore, LMMilligan, JAHajdu, RGollapudi, AKeohane, CALingham, RBMandala, SMDeMartino, JATong, XWolff, MSteinhuebel, DKieczykowski, GRFleitz, FJChapman, KAthanasopoulos, JAdam, GAkyuz, CDJena, DKLusen, JWMeng, JStein, BDXia, LSherer, ECHale, JJ 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem55:2945-59 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prolyl hydroxylase EGLN2
Name:Prolyl hydroxylase EGLN2
Synonyms:EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:Protein
Mol. Mass.:43657.01
Organism:Homo sapiens (Human)
Description:Q96KS0
Residue:407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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BDBM50385813
n/a
NameBDBM50385813
Synonyms:CHEMBL2043168
TypeSmall organic molecule
Emp. Form.C32H30N6O5
Mol. Mass.578.6178
SMILESCOc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1)C(O)=O
Structure
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