| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase D2 |
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| Ligand | BDBM50385915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_824228 (CHEMBL2044163) |
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| IC50 | 330±n/a nM |
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| Citation |  Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem55:3228-41 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase D2 |
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| Name: | Serine/threonine-protein kinase D2 |
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| Synonyms: | KPCD2_HUMAN | PKD2 | PRKD2 |
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| Type: | Protein |
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| Mol. Mass.: | 96755.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BZL6 |
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| Residue: | 878 |
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| Sequence: | MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL
PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL
VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC
AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS
SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF
NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH
ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR
LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE
MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ
ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA
ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV
ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP
EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA
IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF
AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
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| BDBM50385915 |
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| n/a |
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| Name | BDBM50385915 |
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| Synonyms: | CHEMBL2042135 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25F3N4O2S |
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| Mol. Mass. | 490.541 |
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| SMILES | C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F |r| |
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| Structure | 
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