Reaction Details |
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Target | Tyrosine-protein kinase Lyn |
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Ligand | BDBM50385915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_824235 (CHEMBL2044290) |
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IC50 | 1360±n/a nM |
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Citation | Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem55:3228-41 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lyn |
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Name: | Tyrosine-protein kinase Lyn |
Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
Type: | Protein |
Mol. Mass.: | 58575.92 |
Organism: | Homo sapiens (Human) |
Description: | P07948 |
Residue: | 512 |
Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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BDBM50385915 |
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n/a |
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Name | BDBM50385915 |
Synonyms: | CHEMBL2042135 |
Type | Small organic molecule |
Emp. Form. | C24H25F3N4O2S |
Mol. Mass. | 490.541 |
SMILES | C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F |r| |
Structure |
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