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TargetSerine/threonine-protein kinase Nek2
LigandBDBM50385929
Substrate/Competitorn/a
Meas. Tech.ChEMBL_824216 (CHEMBL2044151)
IC50 318±n/a nM
Citation Innocenti, PCheung, KMSolanki, SMas-Droux, CRowan, FYeoh, SBoxall, KWestlake, MPickard, LHardy, TBaxter, JEAherne, GWBayliss, RFry, AMHoelder, S Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem55:3228-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Nek2
Name:Serine/threonine-protein kinase Nek2
Synonyms:NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:Enzyme
Mol. Mass.:51776.96
Organism:Homo sapiens (Human)
Description:P51955
Residue:445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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  Blast E-value cutoff:
BDBM50385929
n/a
NameBDBM50385929
Synonyms:CHEMBL2042039
TypeSmall organic molecule
Emp. Form.C30H29F3N4O3S
Mol. Mass.582.636
SMILESCC(Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1ccc(CN2CCOCC2)s1)c1ccccc1C(F)(F)F
Structure
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