| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Ligand | BDBM50386310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826598 (CHEMBL2050766) |
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| IC50 | 22±n/a nM |
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| Citation |  Dounay, AB; Anderson, M; Bechle, BM; Campbell, BM; Claffey, MM; Evdokimov, A; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Hayward, MM; Horner, W; Kim, JY; McAllister, LA; Pandit, J; Paradis, V; Parikh, VD; Reese, MR; Rong, S; Salafia, MA; Schuyten, K; Strick, CA; Tuttle, JB; Valentine, J; Wang, H; Zawadzke, LE; Verhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett3:187-192 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 47353.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N5Z0 |
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| Residue: | 425 |
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| Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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| BDBM50386310 |
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| n/a |
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| Name | BDBM50386310 |
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| Synonyms: | CHEMBL2049092 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12N2O3 |
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| Mol. Mass. | 208.2139 |
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| SMILES | COc1ccc2C[C@H](N)C(=O)N(O)c2c1 |r| |
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| Structure | 
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