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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM50386312
Substrate/Competitorn/a
Meas. Tech.ChEMBL_826598
IC50 30±n/a nM
Citation Dounay ABAnderson MBechle BMCampbell BMClaffey MMEvdokimov AEvrard EFonseca KRGan XGhosh SHayward MMHorner WKim JYMcAllister LAPandit JParadis VParikh VDReese MRRong SSalafia MASchuyten KStrick CATuttle JBValentine JWang HZawadzke LEVerhoest PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM50386312
n/a
NameBDBM50386312
Synonyms:CHEMBL2049094
TypeSmall organic molecule
Emp. Form.C10H12N2O2
Mol. Mass.192.2145
SMILESCc1ccc2N(O)C(=O)[C@@H](N)Cc2c1 |r|
Structure
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