| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50386452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827141 (CHEMBL2050425) |
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| IC50 | 13000±n/a nM |
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| Citation |  Baud, MG; Leiser, T; Haus, P; Samlal, S; Wong, AC; Wood, RJ; Petrucci, V; Gunaratnam, M; Hughes, SM; Buluwela, L; Turlais, F; Neidle, S; Meyer-Almes, FJ; White, AJ; Fuchter, MJ Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. J Med Chem55:1731-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50386452 |
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| n/a |
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| Name | BDBM50386452 |
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| Synonyms: | CHEMBL2047680 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14BrN3O2S |
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| Mol. Mass. | 332.217 |
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| SMILES | NN=C(Cc1ccc(O)c(Br)c1)C(=O)NCCS |w:1.0| |
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| Structure | 
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