| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50386475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827185 (CHEMBL2050519) |
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| IC50 | 22±n/a nM |
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| Citation |  Mathieu, S; Gradl, SN; Ren, L; Wen, Z; Aliagas, I; Gunzner-Toste, J; Lee, W; Pulk, R; Zhao, G; Alicke, B; Boggs, JW; Buckmelter, AJ; Choo, EF; Dinkel, V; Gloor, SL; Gould, SE; Hansen, JD; Hastings, G; Hatzivassiliou, G; Laird, ER; Moreno, D; Ran, Y; Voegtli, WC; Wenglowsky, S; Grina, J; Rudolph, J Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. J Med Chem55:2869-81 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM50386475 |
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| n/a |
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| Name | BDBM50386475 |
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| Synonyms: | CHEMBL2047879 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClF2N5O3S2 |
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| Mol. Mass. | 461.894 |
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| SMILES | Nc1ncnc2c(csc12)C(=O)Nc1c(Cl)ccc(NS(=O)(=O)CCCF)c1F |
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| Structure | 
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